D-Mannose Powder

D-Mannose is a simple sugar that occurs naturally in some plants, including cranberries. Although small amounts of D-Mannose are metabolized by the human body, much of it is rapidly excreted in the urine. In the bladder, D-Mannose can adhere to undesirable foreign substances, preventing them from sticking to the lining of the bladder. Because insubstantial amounts of D-Mannose are used by the body, it does not interfere with blood sugar regulation.

The bladder lining is comprised of polysaccharide molecules. Finger-like projections on the cell surface of E. coli bacteria adhere to these molecules, initiating an infection. In the presence of D-Mannose, E. coli preferentially attach to D-Mannose molecules forming a complex which is expelled with the next voiding.

D-Mannose probably works 80-90% of the time because the bacteria disabled by Mannose causes 80-90% of UTI's. Whereas antibiotic treatment radically changes GI bacterial populations required for good health, potentially causing fungal or gastrointestinal infections, D-Mannose removes "bad" bacteria by attachment and voiding

The answer is found in the interaction between D-Mannose and the bacterium found in over 90% of all bladder infections, Escherichia coli ("E. coli"). No, not the infamous E.coli mutants associated with unsanitary food processing that has hospitalized and killed people. It's the normal E.coli found as part of the "normal microflora" in every intestinal tract. But even normal E.coli do not belong in the bladder and urinary tract. In these areas they multiply and become an undesirable infection.

Why doesn't the normal flow of urine from the kidneys through the urethras into the bladder and thence beyond simply carry the E.coli right along with it? What allows the E.coli to "stick" to the inner walls of the bladder and even work their way upward (like Spiderman) in some cases reaching as far as the kidneys?

The "cell walls" of each E.coli are covered with tiny fingerlike projections. The very tips of these projections are an amino acid-sugar complex, a "glycoprotein" also called a "lectin". E.coli "lectins" have the unfortunate capability of enabling the bacteria to "stick" to the inside walls of our bladders and urinary tracts, so they can't be rinsed out by urination.

Fortunately, D-Mannose "sticks" to E.coli lectins even better than E.coli lectin "sticks" to human cells. When we take a large quantity of D-Mannose, almost all of it spills into the urine through our kidneys, literally "coating" any E.coli present so they can no longer "stick" to the inside walls of the bladder and urinary tract. The E.coli are literally rinsed away with normal urination.